Immunoglobulins: Extending the Horizon

This is a high-level technical reference text on new and developing uses of intravenous immunoglobulin (IVIg) , virological safety and other treatment issues, and active areas of relevant clinical and basic investigation. Volume editor Kazatchkine explains the importance of this work in his Foreword: IVIg therapy represents the first-line treatment in humoral immunodeficiencies. It also stands as an alternative or complementary approach to targeted immunointervention for immunomodulation of hypersensitivity states and autoimmune diseases. Thus, normal circulating immunoglobulins are now known to play an important role in the selection of immune repertoires and regulation of immune homeostasis, in addition to their role in host defense against infection.