Physical is the story of a hard-living, happily married, middle-aged American (the author) who gets a three-day "executive checkup" at the Mayo Clinic and is thereby forced to confront his mortality, not to mention glove-wearing doctors and the pair of dominatrix-esque technicians who supervise his stress test quite strictly. James McManus must understand his revised actuarial odds in the light of his not-so-long-lived forebears and the fact that his youngest children are only six and five years old. He has to survive his own cardiovascular system, inherited habits, and genetic handicaps long enough to see Bea and Grace into adulthood. But with so much at stake, and in spite of his terror of death, he may not have the willpower to follow the Mayo clinicians' advice.